Sage Veterinary Science

This podcast with Dr. Jerold Rehg and hosted by Dr. Odete Mendes discusses the classification  of mice hematolymphoid tumors in CD1 mice, their pattern of incidence in regards to the age, sex or feeding status and their morphology, cell composition, organ involvement.  Immunohistochemical (IHC) markers that are diagnostically relevant  for these tumors were also discussed.  Dr Rehg characterized the cellular lineage of spontaneous hematolymphoid neoplasms arising in  female CD-1 mice.  Lymphoblastic lymphomas of T-cell and B-cell lineage were common in mice 12 months or less of age, whereas a wide range of non-lymphoblastic B-cell lymphomas and lymphoblastic T-cell lymphomas were common in mice older than 12 months. Additionally, he discussed the presence of renal hyaline droplets positive for lysozyme observed in aged mice with histiocytic-associated large B-cell lymphomas and myeloid leukemia. Finally, Dr Rehg also discussed the recovery of endogenous ecotropic MuLV genes from CD-1 mice and the expressi