Maps Podcast

Taken from the Psychedelic Science '13 conference this epic talk from Heffter Research Institute Founder, David E. Nichols, explores the depths of the brains relationship with LSD.  This talk will provide a foundation for understanding the importance of 5-HT2A receptors in the brain, now widely believed to be the key brain target for psychedelics. The study of this G protein-coupled receptor (GPCR) has required research efforts across several disciplines. Although it was initially thought to couple only to Gq, leading to activation of phospholipase C, it is now known to couple to multiple intracellular signaling pathways. The unique psychopharmacological properties of psychedelics clearly demonstrate that this receptor has special importance as a critical component of sensory perception in humans, and by extension, may be a key player in mediating consciousness.  David E. Nichols is the founding president of the Heffter Research Institute, named after German chemist and pharmacologist Arthur Heffter, who firs