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COVID-19 led to closure of nearly all schools in the United States, affecting more than 55 million students. Efforts to continue children's education have been highly variable, ranging from remote learning, hybrid and modified in-person instructions. Return to school safely for children and staff is being implemented, again variably. Along with the safety concerns, there are significant concerns about the disruption to the learning process, mental health, nutrition and even safety. I'm in conversation with Dr Anita Gupta, DO, PharmD examining the challenges, risks and considerations in ensuring safe return to school of children nationwide.   Takeaways in This Episode Why it is important to weigh the risks, benefits and challenges to safe return to school.  Factors integral to ensuring safety of children, school staff and the community Who needs to be involved in the planning to ensure a safe and expeditious The CDC's policy to guide opening schools safely. What mitigation measures should be required What par