Empowered Patient Podcast

John Celebi, the President and Chief Executive Officer of Sensei Biotherapeutics, emphasizes the need to develop better patient selection strategies and next-generation therapeutics for cancer patients. Through their Tumor Microenvironment-Activated Biologics platform (TMAb), Sensei develops conditionally active therapeutics designed to be active only within the low-pH tumor microenvironment.  Current pipeline candidates are designed to be active only within the low-pH tumor microenvironment and show potential to overcome the challenges of VISTA, a promising checkpoint target. John explains, "As an industry, we have some tough choices. Other strategies, both within and outside of IO, have made much better progress in targeting which patients will respond and which patients won't respond to treatment. Those are decisions that we have to make as an industry to keep up." "The second one I would point to is that we're now in a decade after the first immuno-oncology drug approval. And so, we have a whole generati