Science Friday

Twenty years ago, scientists found that phenylephrine, listed as a decongestant in many cold medicines, didn’t work. What can you use instead? In September, an advisory committee for the Food and Drug Administration unanimously confirmed that phenylephrine—a common ingredient in cold medicines, including some types of Mucinex and Robitussin—doesn’t work.For many physicians, pharmacists, and cold-sufferers, this came as no surprise. Phenylephrine’s ineffectiveness had been an open secret in the healthcare community for decades.In 2005, Dr. Randy Hatton, clinical professor at the Pharmaceutical Outcomes and Policy Department at the University of Florida, managed the University of Florida Drug Information and Pharmacy Resource Center hotline. He often received calls from pharmacists reporting that phenylephrine-based drugs had no effect on improving colds.He came across research from Dr. Leslie Hendeles, professor emeritus of the College of Pharmacy, also at the University of Florida, from a decade prior. Dr. He