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Angel Scale Biotech: Learn More   Growing new cartilage in your knees is a dream about to become reality. Listen to Ben Holmes, PhD, co-founder of Nanochon, to learn about his promising technology. Shoutout to Richard Meiklejohn of M2D2 for the introduction.    Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces Ben Holmes What Problem Nanochon is Solving "... That's really what we're looking to do, is offer a solution that can be a much easier, much more cost-effective solution for providers, but also something that can really provide much better short and long-term outcomes for patients, and, ultimately, make the knee replacement obsolete..." The Solution: What it is, and How it Works "... We're seeing much better repair, and we're doing it with something that's an easy-to-use, off-the-shelf product..." What is I-Corps? Future Funding Plans Names and Numbers Ben's Entrepreneurial Journey Advice to the Audience   Topic

Angel Scale Biotech: Learn More   During COVID, Readlee, Drew Madson’s startup, offered teachers a highly effective way to measure and remedy reading deficits among online learners. This led to the company being acquired by Paper, the tutoring platform. An inspiring interview.   Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces Drew Madson What Readlee is Solving Behind the Scenes of Readlee How Readlee Came to Be "... COVID just highlighted this need that already existed..." "...I highly recommend checking out The Opportunity Atlas. If listeners haven't looked at this, it's an amazing analysis of how certain interventions can actually improve people's ability to make more money over the course of their lives and have more opportunity and flourishing..." "... What are large language models going to do to this space?..." How Drew Developed an Interest in Education Parting Thoughts   Topics: discovering entrepreneurship

Angel Scale Biotech: Learn More   Tech founder David Kessler discusses his journey as an angel investor in companies such as CleanFiber, Wasabi, and Hilltop Bio.   Sponsored by Purdue University enrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces David Kessler "... This is like a very counterintuitive investment for angel investors, but it was angel-funded..." The Importance of Updates What Hilltop Bio Does "... This is why I want to create infrastructure to help the angels support these academic founders with connections..." Wasabi "... helping founders hone their messaging, hone their presentation..." "... Basically, the question is, what other ways of looking at the world are there and are you flexible enough to say that there are other ideas out there, and you may wind up pivoting into one of those..." How David Kessler Got into Angel Investing "... Start slow, start small, and don't invest alone..." Advice to the Audience   Topics: angel investin

Angel Scale Biotech: Learn More   Salvatore Viscomi, M.D. is CEO of Carna Health, a digital platform that is making it easier for patients with chronic conditions to do tests at home that would normally have to be done in the hospital.   Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces Salvatore Viscomi What Carna Health is Solving "... We connect the device to our platform, we collect the data, we stage the disease, and then we share that information with the patient-provider..." "... The solution is really to bring the testing to the community, identify the 90% of people that don't know they have it, let them know they have it..." "... The devices on their own without connectivity and without a platform are really not a scalable solution for the type of programs that are needed to make an impact on these diseases ... The doctors are connected through a physician portal, and we identify all the people that are being

Angel Scale Biotech: Learn More   Nick LaRovere and Matt Hawkins co-founded Pryzm.io seeking to simplify the process of buying a home via technology.   Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces Nick LaRovere and Matt Hawkins What Pryzm.io is Solving "... Nick and I are both technical co-founders. We love building things, and so we're really excited to actually have our product in the hands of our early agent partners here in Boston..." "... We take what is previously only agent-facing tooling, and we flip it around so that the consumer can really take charge of their own transaction. They can be empowered to work autonomously..." The Importance of Renter's Insurance "... real estate is a very congested space from technology perspective. What Pryzm is really trying to do is be that foundational information layer that the rest of the real estate experience can evolve from..." "... at Pryzm we are ver

Coach Jina Klapisch who helps Sal Daher keep off 100 pounds is our guest in this episode. Sal and Jina discuss how HMR clients are able to take off and keep off significant weight with no hunger or feeling of deprivation. Check out HMR Weight Loss and Lifestyle Coaching at: https://www.hmrnatick.com/about_us Highlights: ●  Sal Daher Introduces Jina Klapisch ●  What Sets HMR Apart From the Rest ●  How HMR Works ●  "... What you're doing here is helping people discover the things that are easy for them to do repeatedly and make them into habits, and not try to do stuff that's hard, impossible for them..." ●   Decision-Free ●   Sal's Diet Journey at the Age of Thirteen ●   Oprah and HMR ●    "... when you're trying to make a very big change in your life, whether it's quitting smoking or quitting drinking, or with food, you need to take a break from that substance ... so that you can see clearly as you lose this weight and start to really figure out who I am as an eater..." ●  How Your Environment Can Affect Your

After recording the full episode titled “Tech & Weight Control” I realized I left out some important technologies I use in making the shakes that support my keeping off 100 pounds. So, here’s a mini-episode with that staircase wit, as the French call it. Highlights: ·      Ninja Creami Ice Cream Maker ·      Ninja Bullet & Cuisinart Mini-Prep Plus Are Smaller & Cheaper Alternatives ·      Shaker Bottles Are Real Calorie-Savers ·      Acaia Digital Scale   Topic:              Healthy Aging Guest:             Sal Daher Title:                Staircase Wit: Shake Tech

Technology has long conspired against our health by making us fatter, more sedentary and sleepless. However, we can recruit tech as our ally in building healthy habits. Here is a review of the tech that is helping me keep off 100 pounds.   Highlights:   ·      Tech Can Make Us Less Healthy but It Can Be Good for Us Too ·      Getting Help in Weight Loss Is Really Powerful, You Can’t Do It Alone ·      MyFitnessPal App ·      Noom App ·      Fitbit Charge 4 Tracker + Fitbit App ·      WHOOP Band and App ·      Shoutout to the Great Products from Hoplark ·      Plenity, FDA-Cleared Weight Control Device (Does Not Act Systemically) ·      “I used it [Plenity] as an on-ramp for my HMR diet...” ·      Fitbod ·      Life Fitness Elliptical Cross-Trainer ·      NordicTrack Cross Country Exerciser ·      Tonal ·      Bowflex SelectTech ·      $19.99 Chin-up Bar from Amazon ·      Marathon Sports ·      PowerStep Arch Support ·      The Drive: Podcast with Peter Attia, M.D. ·      Huberman Lab Podcast ·      HMR: fo

Angel Scale Biotech: Learn More   Getting enough sleep is important to Sal Daher’s effort to keep off 100 pounds. This short episode discusses how sleep connects with weight and how to improve sleep in support of weight control.   Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Why We Don’t Sleep Enough Markets & Technological Innovation Are to Blame but the Solutions Need to Come from Individuals and Voluntary Associations, not from Leviathan We Know We Need to Sleep More but the Cards Are Stacked Against It Why Is Sleep So Important to Weight Control? As We Age Our Need for Sleep Does Not Decline but Our Ability to Sleep Does Why I do Early Morning Exercises Outdoors – GoodLux Technologies Huberman Lab Podcast Offers Valuable Tips   Topic: Healthy Aging

Angel Scale Biotech: Learn More   Sal Daher, CFA discusses the role of exercise in his keeping off 100 pounds of body weight with no drugs and no surgery, just good habits for eating, exercising and sleeping. Listen for tips and for encouragement on building your exercise plan.   Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Why Exercise? How Much Exercise Do I need? Don’t Get Overly Ambitious – Start Slowly but Build Steadily Within Safe Limits Do Try to Get Out of Your Comfort Zone – Here’s Why Think You Can’t Exercise? Listen to These Stories Then, Tell Me You Can’t Exercise No Financial Stake in HMR, Just Immense Gratitude for How Much They Have Helped Me It Matters When You Exercise Short Bouts Build Up Do a Variety of Exercises Zone 2 / Zone 5 Training Exercise Has an Unexpected Side Effect for Me I’ve Never Regretted Exercising   Topic: Healthy Aging

Nearly two years after starting the effort to take off and keep off 100 pounds, I took a series of trips. Here’s how I coped with the challenges of being on the road and maintaining my weight. Highlights: ·      Trips to Napa Valley, Hamburg and San Sebastián Took Me Away from my Usual Supports ·      Travelling Heavy to Napa Valley ·      “…there may be people who can travel and not gain weight. But I’m not one of them. Therefore, I have to do unreasonable things to keep off those 100 pounds.” ·      Traveled Ultra-light to Hamburg – Just Carry-on ·      A Thought about the Effects of Alcohol on Sleep ·      Traveled Medium-heavy to San Sebastián – 23 Days Away Is a Long Time

I’m Sal Daher and I’m keeping off 100 pounds of body weight with no drugs and no surgery. I’m doing it by building and reinforcing healthy habits. I eat a lot but do not put on weight. It was not easy to build the healthy habits I practice but it can be done. Highlights: ·      Introduction ·      Food Intake Is the Main Driver of Weight Management, Not Exercise ·      Repeatable Changes You Can Live With ·      What I Eat for Lunch Regularly Now ·      My Fat but Fit Delusion ·      Your Longevity Is Up to You, Nature Does Not Care About It ·      I Could Not Change My Habits Alone, Not Even in Singapore ·      I Needed Help to Build and Maintain My New Habits ·      A Cool Mind Trick ·      There’s a Reason They Are Called “Support Groups” ·      Getting Back to Diet – Here’s What I Eat Throughout the Day ·      Breakfast – This One Is for You Ralph Wagner ·      Hydration Is Really Crucial – Always Trying Cool New Drinks ·      Mid-morning Snack – Efficiency Is the Keyword ·      Lunch – See Above – But T

Angel Scale Biotech: Learn More   Layne Sadler founded KeyBio to help pharmaceutical companies better identify genetic traits in patients that may explain differing responses to cancer treatments. KeyBio’s computational approach promises to add a new dimension to precision medicine, which now looks at the genetics of the tumor, by also incorporating the genetics of the patient to improve outcomes in clinical trials.   Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces Layne Sadler What KeyBio is Solving "... The revenue is solely focused on cancer drug discovery and the reason for that is because that's where all the money is in the pharmaceutical industry..." "... 90% of clinical trials fail and the cost averages around 792 million, spending about a billion dollars to run a trial..." "... I developed this AI platform and I wanted to start collaborating with other principal investigators or heads of labs in the Boston a

Angel Scale Biotech: Learn More   After a career at DARPA, defending America from cyber threats, Jason Syversen founded Siege Technologies which had a great exit. He now focuses on angel investing and philanthropy. Inspiring chat.   Sponsored by Purdue University entrepreneurship, and Peter Fasse, patent attorney at Fish and Richardson.   Highlights: Sal Daher Introduces Jason Syversen What Problem Siege Technologies is Solving "... How do you measure and predict probability of success and collateral damage for a cyberattack? That is actually the technology we end up being acquired for when we sold..." "... I took over 10X Venture Partners, which is an angel group..." SportsVisio and What it is Solving "... That was a really interesting example of you think that this is all figured out even in pro leagues, and yet it really isn't..." Jason's Background "... if you had a choice between being born in a family with trust funds where your parents really don't care about you or being born in a hardscrabble famil

Losing and keeping off 100 pounds is hard. Having done it, Sal wants to convince you that you too can gain control of your weight. No drugs, no surgery, just new habits patiently created and reinforced. Sal’s daughter Grace Daher conducted this frank interview. Highlights: Here’s the Story of How Sal Daher Lost 100 Pounds with No Drugs and No Surgery –  You Can Do It Too Sal Introduces His Daughter Grace Daher Who Is Asking the Questions When Sal Was First Told He Needed to Lose Weight A Big 13-Year-Old on a 1,300 Calorie Diet – Misery! Early On It Was Evident that Sal Was Triggered by Food but His Brother William Was Not Sal Became More Active in College but Bad Diet Caused Weight Gain Lost Weight During Summer Break in Brazil – Less Eating More Moving Sal Was Fit in College, But Still Overweight – Did Not Realize the Burden He Was Carrying Around Sal Got Down to His Ideal Body Weight in His Mid 30s Out of Concern for His Blood Pressure Lost the Weight on the HMR Program – No Hunger – More Is Better How the

With minimal funding, Gloria Kolb and her husband Eric Kolb have created a device to treat urinary incontinence that has received a coveted clearance from the FDA. Elidah, their startup, expects to exceed $3 million in DTC sales this year. I really enjoyed this story of a couple bootstrapping a promising business together. Highlight: ·       Sal Daher, CFA Introduces Gloria Kolb, Co-Founder of Elidah ·       Elidah Is Solving Urinary Incontinence in Women – Device Induces Kegel Exercises ·      Just Got FDA Clearance for Overactive Bladder ·       “She only needs to wear it for 20 minutes a day, and then it turns off automatically.” ·       Differentiation from Other Devices: FDA Cleared for Incontinence ·       Randomized Control Trial Result: 75% of Women Experienced Statistically Significant Improvement ·       “It drives me crazy that women do wait so long and they don't tell anyone and they just deal with it for a long, long time. I think part of it is they don't think that there's any other good

Spinal fractures from osteoporosis cause many to lose their independence. Industry veteran Dom Messerli has a better way of fixing the problem than the risky practice of injecting liquid epoxy into the spine. Using engineered human bone, Lenoss Medical is offering a treatment that is safer, effective and easier to administer than the current standard. Highlights: ·      Sal Daher, CFA Introduces Dom Messerli, Founder of Lenoss Medical ·      “Many times, the patients lose their independence when those fractures happen.” ·      Current Standard of Care is to Inject Liquid Epoxy into the Spine – What Could Go Wrong? ·      Liquid Epoxy Can Leak into Blood Vessels and Create Blockages ·      “When it's in the heart, usually what's prescribed is open heart surgery to take out the piece of cured cement out of the heart.” ·      Lenoss Medical’s Solution: Engineered Human Bone Material to Build Up the Weakened Spine ·      Grafting of Same-Species Bone Material Is Decades Old – What’s new Is Applying the Approach

A miserable New England day had avid cyclist Eric Janszen dreaming of better indoor riding. Together with co-founder Eric Malafeew, he launched VirZOOM which now has 40,000 users on its virtual reality platform with great engagement. Fascinating conversation about virtual games becoming sport. Highlights: ·      VirZOOM Gets Grant from Major VR Player for a Joint Development Project ·      Sal Daher Introduces Eric Janszen, Co-Founder of VirZOOM ·      Ongoing Crowdfunding Raise on StartEngine ·      VirZOOM Meets the Challenge of Helping People Enjoy Exercise ·      Technical Co-Founder Eric Malafeew Worked on Big Hits at Harmonix Music ·      VirZOOM Tech Lets Users to Do Cool Things Without Getting Motion Sickness ·      Broke Out of the Limitations Imposed by Being a Bike-Based Platform ·      “It sounds like you could actually play Quidditch on this.” ·      How the Pivot Came About ·      “Where we're heading is 100% without a bike.” ·      Making It a Sport Rather than a Game Has Huge Economic Consequ

Caleb Wursten is an entrepreneurial prodigy who paid for college at Babson with a bike rental business. He’s now building a platform to provide digital nomads with fractional ownership of properties in desirable locations. International business executive Jon Aboitiz joined as co-host. Highlights: ·       Sal Daher Introduces Co-Host Jon Aboitiz and Caleb Wursten, Founder of Worldhaus.co ·       “The pandemic unlocked this digital nomad lifestyle for millions of people.” ·       Getting Expensive to Be a Digital Nomad as Airbnb Prices Go Up ·       Fractional Ownership vs. Timeshares ·       Owning 1/13 of Properties in Desirable Locations via an LLC ·       “You're addressing a key factor, it seems, which is the cost of living and how to make it even more affordable...” ·       “The first property is a $220,000 condo in Playa del Carmen, Mexico.” ·       Can Choose Between Occupancy or Renting for Income ·       Comparison to Fractional Ownership of Yachts ·       Developers Are Responding to Dem

Angel investor John Williams comes from a background of leadership in sales and marketing in Big Pharma. He puts his experiences to work in helping his portfolio companies which include Lenoss Medical, Elidah and Eflex Energy. John’s affable personality made this really a fun chat.   Highlights:   ·      Sal Daher Introduces Angel Investor John Williams ·      Elidah – Solving Postpartum Incontinence ·      Gloria Kolb of Elidah Embodies Howard Stevenson’s Definition of the Startup Founder ·      Lenoss Medical: Better Treatment for Fractures of the Spine Due to Aging ·      “...a guy who's 63 years old made the cut at the Masters this weekend. They [seniors] have higher expectations...” ·      No More Heart Attacks in 40 Year Olds Thanks to Statin Drugs Controlling Blood Lipids ·      “It's also fun to watch pitches. Because you're like, "Wow."” ·      Robotic Gloves Keep popping Up in Sal’s Angel Investing Career ·      Eflex Energy: Load Management for Your Home Backup Power ·      “I would have been able