Sage Veterinary Science

ISFM Consensus Guidelines on the Diagnosis and Management of Hypertension in Cats: Samantha Taylor talks to Jennie Atkinson from SAGE about the ISFM guidelines on diagnosis and management of hypertension in Cats. Posted June 2017.

John Lewis, editor-in-chief of the Journal of Veterinary Dentistry, interviews Dr. Colin Harvey. The official podcast of the Journal of Veterinary Dentistry, “Veterinary Dentistry Matters,” provides interviews with those who influenced the specialty during its inception and with those who continue to affect its trajectory. In addition to interviews with our specialist colleagues, the podcast will be an opportunity to discuss specific authors’ manuscripts in further detail and popular topics as they arise.

In this podcast, Associate Editor Denise Bounous discusses the February 2017 Special Issue with guest editors Adam Aulbach, Holly Jordan, and Jacqueline Tarrant. The editors discuss Contemporary and Emerging Applications in Clinical Pathology and provide information on the articles in the issue.   Click here to read the issue.  

John Lewis, editor-in-chief of the Journal of Veterinary Dentistry, presents the inaugural podcast for the journal by interviewing Dr. Mark Smith, the longest tenured editor of the journal. The official podcast of the Journal of Veterinary Dentistry, “Veterinary Dentistry Matters,” provides interviews with those who influenced the specialty during its inception and with those who continue to affect its trajectory. In addition to interviews with our specialist colleagues, the podcast will be an opportunity to discuss specific authors’ manuscripts in further detail and popular topics as they arise.

In this podcast, Dr. Sydney Mukaratirwa discusses this study which was conducted to characterize lung microscopic lesions in control beagle dogs from inhalation and oral gavage toxicity studies, to determine differences associated with the route of administration, and to discuss distinguishing features from compound-induced lung lesions. 

In this Toxicologic Pathology podcast, Stacey L. Fossey interviews author Peter Hall on his article "Femoral Head Growth Plate Dysplasia and Fracture in Juvenile Rabbits Induced by Off-target Antiangiogenic Treatment." Epiphyseal growth plate dysplasia (chondrodysplasia) might be considered as the pathognomonic feature of antiangiogenic treatment in preclinical species as it is reliably and dose-responsively induced in rodents and monkeys with vascular endothelial growth factor receptor (VEGFR) inhibitors, fibroblast growth factor (FGF) receptor inhibitors, matrix metalloproteinase inhibitors, and vascular targeting agents. The article suggests that the high prevalence of growth plate fracture in the rabbit may represent a potential additional adverse risk to those already established for children treated with antiangiogenic therapy.

The AAFP Guidelines for the Management of Feline Hyperthyroidism (FHT) help primary clinicians answer common questions and suggest when referral may benefit the feline patient. The Guidelines shed light on FHT as a disease and also dispel myths surrounding certain aspects of FHT by replacing them with evidence-based narrative veterinary professionals can directly apply to feline patients and their owners. Listen to Dr. Margie Scherk interview Dr. Hazel Carney about her work on the FHT Guidelines.

ISFM Consensus Guidelines on the Diagnosis and Management of Feline Chronic Kidney Disease: Jennie Atkinson from SAGE talks to Dr Andy Sparkes about the ISFM Consensus Guidelines for Feline Chronic Kidney Disease. Posted: March 2016

This podcast, with Dr. James D Fikes, from Biogen, focuses on the Guidance on the GLP Requirements for Peer Review of Histopathology (guidance # 16) published on September 26, 2014 by the Economic Co-operation and Development (OECD). This guidance represents the first such guidance specifically on the process of Peer Review, which is a widely used tool to assure objectivity and accuracy of histopathology data by submitting it to peer analysis and discussion, before becoming official. This guideline is binding for regulatory filings in Europe and is expected to influence practices of other regulatory agencies. The Society of Toxicology Pathology, through its Scientific and Regulatory Committee, undertook a thorough analysis and provided further interpretation of this guideline in order to assist toxicologic pathologists and other scientists interested in the development of medicines, so that the guidance is better implemented in a unified fashion. This guidance clarifies some concepts, such as what is raw

This podcast with Dr. Jerold Rehg and hosted by Dr. Odete Mendes discusses the classification  of mice hematolymphoid tumors in CD1 mice, their pattern of incidence in regards to the age, sex or feeding status and their morphology, cell composition, organ involvement.  Immunohistochemical (IHC) markers that are diagnostically relevant  for these tumors were also discussed.  Dr Rehg characterized the cellular lineage of spontaneous hematolymphoid neoplasms arising in  female CD-1 mice.  Lymphoblastic lymphomas of T-cell and B-cell lineage were common in mice 12 months or less of age, whereas a wide range of non-lymphoblastic B-cell lymphomas and lymphoblastic T-cell lymphomas were common in mice older than 12 months. Additionally, he discussed the presence of renal hyaline droplets positive for lysozyme observed in aged mice with histiocytic-associated large B-cell lymphomas and myeloid leukemia. Finally, Dr Rehg also discussed the recovery of endogenous ecotropic MuLV genes from CD-1 mice and the expressi

Veterinary Pathology podcast editor Leah Schutt discusses the the article, "Autosomal Recessive Congenital Ichthyosis in American Bulldogs Is Associated With NIPAL4 (ICHTHYIN) Deficiency" with Dr. Mauldin and Dr. Casal, two of the authors of the study. To view this article, click here.

This podcast with Dr. Sam Cohen and hosted by Dr. Peter Hall  concerns the publication of a STP committee chaired by Dr. Charles Wood concerning the role of increased cell proliferation in the evaluation of the mode of action of carcinogenesis, particularly for nongenotoxic chemicals.  Dr. Cohen emphasizes the importance of attention to details in assessing cell proliferation, with different approaches necessary for various tissues and circumstances.  He also emphasizes that the focus is on the number of cell replications, not necessarily the rate, and that it is the tissue stem cell population that is critical.  For nongenotoxic chemicals the mode of action always involves an increase in cell proliferation, and this can be utilized in designing a short (e.g. 90 days) study to screen for carcinogenesis in rodents.  Such a screen requires a labeling index (BrdU, Ki-67, PCNA) in addition to standard histopathology.  If positive, additional short term studies can be performed to evaluate the dose response in det

Veterinary Pathology podcast editor Leah Schutt discusses the the article, "A Comparison of Biochemical and Histopathologic Staging in Cats With Chronic Kidney Disease" with Dr. Quimby, one of the authors of the study.   To view this article, click here.

This podcast with Dr. Jeff Wolf discusses the development of a career in the specialized field of fish pathology, and the use of fish in biomedical and environmental research.  As a veterinary pathologist, Dr. Wolf became involved with fish research during his graduate studies and as part of his present job with EPL.  Major uses of fish in toxicology include endocrine disruption research, toxicity screening, assessment of environmental contaminant effects, target animal safety studies (e.g., fish pharmaceuticals), and carcinogenesis research, the last of which was originally prompted by findings of endemic tumors in fish from polluted waters.  Dr. Wolf recently collaborated with 17 other fish pathologists in a Toxicologic Pathology review article that describes and illustrates some common diagnostic misinterpretations evident in the peer-reviewed fish literature, and makes recommendations for improving the quality of papers that publish fish histopathology data.  Dr. Wolf participates in numerous meetings and

Veterinary Pathology podcast editor Leah Schutt discusses the the article, "Prognostic Value of Histologic Grading for Feline Mammary Carcinoma: A Retrospective Survival Analysis" with Dr. Simko, one of the authors of the study.   To view this article, click here.

Veterinary Pathology podcast editor Leah Schutt discusses the emerging field of veterinary forensic pathology with Sean McDonough, who co-authored the editorial “Illuminating dark cases: veterinary forensic pathology emerges”, which will appear in the January 2015 edition.  Dr. McDonough is a veterinary pathologist at Cornell University with a significant commitment to applying the principles of forensic pathology to investigate animal abuse and neglect cases.   To view this article, click here.

  Feline Dentistry: Jennie Atkinson from SAGE talks to Rachel Perry, guest editor for the two special issues on Feline Dentistry published in the Journal of Feline Medicine and Surgery – vol 16:11 and 17:1 respectively. Rachel is a leading figure in feline dentistry based in the South East of England and Rachel lectures internationally on veterinary dental issues.  

Thomas Rosol discusses the role of tumor microenvironment on cancer metastasis in a murine breast cancer model with Leah Schutt. Dr. Rosol coauthored the paper entitled “Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-PymT mammary cancer cells in vivo” in the July 2014 edition of Veterinary Pathology. Dr. Rosol is a Professor and Advisor for the Life Sciences, Technology and Commercialization Office at The Ohio State University.   To view the article, click here.

Leah Schutt discusses an emerging systemic ciliated protozoal disease of aquarium sharks with Mark Stidworthy, who co-authored the paper entitled "Systemic Scuticociliatosis (Philasterides dicentrarchi) in Sharks" in the May 2014 issue of Veterinary Pathology. Dr. Stidworthy is a zoo and wildlife pathologist working in the United Kingdom.   To view the article, click here.

Sean Callanan talks with author, John Ellis, about his article: "Porcine Circovirus: A Historical Perspective."   To view this article, click here.